Taken together with our finding that knockdown of SNRPD3 in MYCN-high expressing cells resulted in greater reduction of cell viability when compared to MYCN-low expressing cells (Fig. 2G), we propose that the skipping of exon 3 in BIRC5 and intron 7 retention in CDK10 are toxic splice events in MYCN-driven neuroblastoma which are prevented by SNRPD3 in MYCN driven cancer cells. The gene discussed is BIRC5; the disease is cancer.