Multiple studies observed high number of FLT3 mutations in high-risk subtypes, such as Ph-like ALL [32, 33] or patients who relapse [32], as well as an association with age, including infant patients with MLL/KMT2A rearrangement and adults with early T-cell precursor ALL (ETP-ALL) [34, 35]. This evidence concerns the gene KMT2A and acute lymphoblastic leukemia.