CDKN1A and Glucose intolerance: Furthermore, AAV8-shHmmr mice at dpc16 exhibited lower liver glycogen concentrations (Fig. 6f), increased glucose intolerance (Fig. 6g, h), greater placental glycogen deposition (Fig. 6i) and fetal overgrowth (Fig. 6j, k) compared to AAV8-null mice, all recapitulating AAV8-p21 mice (see Fig. 4).