CXCR5 is the receptor of C-X-C motif chemokine ligand 13 (CXCL13); CXCL13/CXCR5 signaling axis activity can accelerate the progression of colorectal carcinoma by activating the PI3K/AKT pathway55. The gene discussed is CXCL13; the disease is colorectal carcinoma.