To understand the relationship between Gαi1-driven NPC cell growth and Akt-mTOR cascade activation, a S473D constitutively-active mutant Akt1 (caAkt1) was stably transduced to Gαi1-silenced pNPC-1 cells (with “Gαi1-shRNA-s2”, see Fig. 3). This evidence concerns the gene MTOR and nasopharyngeal carcinoma.