For these perspectives, we herein synthesized a reduction‐sensitive NO donor conjugate of furoxans–gemcitabine (Gem, a RAD51 inhibitor) (NG) as radio‐sensitizer and then rationally designed a CCL5 peptide‐modified bioinspired lipoprotein system of NG (C‐LNG), aiming to preferentially target the GBM tumor sites and potentiate the RT efficacy (Figure 1H). This evidence concerns the gene RAD51 and neoplasm.