TJP1 and periodontal disorder: There is an increase in E-cadherin localization and E-cadherin expression permitting an upregulation of the epithelial barrier function.84Human keratinocyte cells, when treated withBifidobacterium longumATCC 51870, demonstrated an increase in expression of TJ proteins, increasing the epithelial layer integrity.46Streptococcus gordoniihas the ability to increase ZO-1 and ZO-2 expressions in monolayered oral epithelial cells.46A schematic representation of the potential modes of regulation of cell junctions for management of periodontal disease is given inFig. 3.