CTLA4 and glioblastoma: The attempt to inhibit the CTLA-4 activity was pursued in a phase II clinical study on anti-CTLA-4 that is currently examining temozolomide treatment alone vs temozolomide with ipilimumab (anti-CTLA-4 monoclonal antibody) in patients with GBM after standard treatments.39 This trial is currently recruiting in 7 centers in the UK.