KDR and glioblastoma: VXM01 is a DNA plasmid vaccine that contains an attenuated strain of Salmonella typhimurium, which encodes the murine vascular endothelial growth factor receptor 2 (VEGFR-2) whose activation enhances angiogenesis and cell proliferation and is commonly expressed within the tumor microenvironment.74 NCT02718443 showed a favorable response in 5 patients with recurrent GBM.