NFE2L2 and goiter: We have previously shown that mice exhibiting enhanced Nrf2 function due to Keap1 hypomorphism show higher expression of antioxidant genes and increased degradation of Tg, and they develop a goiter (thyroid enlargement) phenotype that is characterized by increased thyroid follicle size, thyroid weight and TSH levels, indicating the presence of subclinical hypothyroidism [10].