Using ApoA1 as a global marker for total HDL expression, the greatest reduction in SLE was in Group 2 (P < 0.0001), followed by Group 1 (0.00020), and then Group 3 (P = 0.018) (Fig. 1C), which was supported by ROC analysis (AUC = 73.70, 71.40 and 60.76, respectively, and AUC = 67.38 for all patients combined when compared with HCs, Supplementary Fig. S2A, available at Rheumatology online). The gene discussed is APOA1; the disease is systemic lupus erythematosus.