In our current study across age in SLE, we found that both small- and medium-sized HDL subsets, as well as the HDL peptide region, ApoA1, were decreased in SLE patients in all age groups compared with HCs, particularly in the younger age groups and those with active disease, supporting previous studies in JSLE and the ‘lupus pattern’ of dyslipoproteinemia described by Borba and Bonfá [13]. Here, APOA1 is linked to systemic lupus erythematosus.