We estimated univariate Kaplan-Meier survival curves in our analytic sample (NPerson-years = 117,142) using age at first indication of cognitive impairment and found statistically significant differences across APOE-ε4 genotype according to a log-rank test (χ2(2) = 99.25, P<0.001) (Fig 2, Panel A). The gene discussed is APOE; the disease is Cognitive impairment.