We observed that possession of one (HR = 1.25, 95% CI [1.16–1.35], P<0.001) or two copies (HR = 1.68, 95% CI [1.36–2.09], P<0.001) of APOE-ε4 resulted in significantly greater hazard for developing cognitive impairment in later life (Model S1.1). This evidence concerns the gene APOE and Cognitive impairment.