Cell lines derived from Burkitt’s lymphoma (Ramos), mantle cell lymphoma (Jeko-1), germinal center B-cell-like diffuse large B cell lymphoma (SU-DHL-6), and activated B-cell-like diffuse large B cell lymphoma (SU-DHL-2) were highly susceptible to PTDSS1 inhibition, whereas lines derived from acute lymphoblastic leukemia (RS4;11 and NALM-6) and multiple myeloma (MM.1S), as well as most solid-tumor lines, were less sensitive. The gene discussed is PTDSS1; the disease is Burkitt lymphoma.