It is reported that the PBRM1 protein is involved in various DNA repair mechanisms and is critical for cohesion between centromeres, necessary for maintaining genomic stability and loss of PBRM1 in ccRCC dampens p53 function and especially p21 expression, which is key for cell cycle arrest and senescence [37, 38]. Here, TP53 is linked to nonpapillary renal cell carcinoma.