It was also reported that hypermethylation in promoter region of several tumor suppression genes, such as PCDH17, NEFH, GREM1, GATA5, LAD1, NEFH, NEURL and SFRP1, was associated with poor survival of ccRCC patients [46–48]. Here, LAD1 is linked to nonpapillary renal cell carcinoma.