CCND1 and colorectal cancer: The CyclinD1 and β-catenin expressions within the Wnt pathway, were significantly decreased following down-regulation of EZH2, suggesting that down-regulation of EZH2 was capable of suppressing the Wnt/β-catenin signaling pathway activation and perhaps facilitated RUNX3 expression via that pathway, thus inhibiting colorectal cancer from developing.