Model 1 output is detailed in Table 2 and shows that years of education (HR, 1.16; 95% CI, 1.03-1.28) and possessing 1 or more copies of the APOE*E4 allele (HR, 2.10; 95% CI, 1.11-3.99) were significantly associated with cognitive impairment. This evidence concerns the gene APOE and Cognitive impairment.