APOE and Cognitive impairment: Within model 3 (Table 2), several factors were found to be significantly associated with the risk of cognitive impairment, including years of education (HR, 1.25; 95% CI, 1.10-1.42), APOE*E4 status (HR, 2.74; 95% CI, 1.38-5.44), exhibiting a short sleep phenotype (HR, 3.67; 95% CI, 1.59-8.50), and having higher sleep variability (HR, 3.06; 95% CI, 1.14-5.49).