Besides, it is conceivable that SGLT2 inhibitors (SGLT2-i) or GLP-1 receptor agonists (GLP-1 RA) could influence cardiovascular mortality in T2D patients, our analysis was limited by the absence of specific identification for SGLT2-i or GLP-1 RA medications in the NHANES database. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.