GSK3B and neoplasm: Sarcomas derived from Tp53-H; Prl2-KO mice also showed reduced mTORC1 and GSK3β phosphorylation compared with Tp53-het–derived tumors, in accordance with reduced tumor proliferation observed (29.2% reduction, P = 0.0473, and 44.7% reduction, P = 0.0465, respectively Supplementary Fig. S4A–S4C).