TP53 and neoplasm: To bypass major postnatal development, 8 to 10 weeks old adult mice were given tamoxifen intraperitoneally for 5 consecutive days to induce Tp53 and/or Prl2 whole-body deletion to generate the control Tp53−/− and experimental Tp53−/−; Prl2−/− mice, which were monitored for tumor development and survival (Supplementary Fig. S2B).