Our results show that simultaneous inducible deletion of Prl2 and Tp53 significantly hinders thymic lymphoma growth rate (Tp53−/− vs. Tp53−/−; Prl2−/− at 12 weeks 0.419 g vs. 0.098 g, P = 0.0017; at 16 weeks 1.083 g vs. 0.594 g, P = 0.0085; Fig. 3D). This evidence concerns the gene TP53 and thymus lymphoma.