The high c-FOXP3+E-Cadherin− cells group (high c-FOXP3+E-Cadherin− cells group >4 cells/high-power field and low group ≤4 cells/high-power field) correlated with unfavorable clinicopathological parameters, including poorer tumor differentiation, lymph node metastasis, vascular invasion, and the count of Tregs (all P < 0.001) (Table 1). Here, FOXP3 is linked to neoplasm.