HMGCR and rheumatoid arthritis: For the traditional drug target MR analysis, the IVW showed a causal relationship between HMGCR-mediated LDL cholesterol and risk of RA (OR=0.995, 95% CI =0.991–0.998, p= 0.007), a similar result was observed in the weighted median method (OR=0.996, 95% CI =0.991–0.999, p= 0.044), further supporting a possible higher risk of HMGCR inhibitors on RA.