Similarly, hydroxymethylglutaryl coenzyme A reductase (HMGCR)-mediated low-density lipoprotein cholesterol was negatively associated with risk of RA (OR=0.995, 95% CI =0.991–0.998, p= 0.007) in the inverse variance weighted (IVW) method. This evidence concerns the gene HMGCR and rheumatoid arthritis.