In IVF cycles, the use of the GnRH antagonist protocol, coasting protocol, low initial gonadotropin dose, aspirin, calcium, the GnRH agonist trigger, and the whole embryo freezing strategy should be considered for patients with HOR to reduce the likelihood of OHSS, venous thrombosis, and other hazards in patients (27). This evidence concerns the gene GNRH1 and ovarian hyperstimulation syndrome.