Studies have shown that SGLT2 inhibitors can improve urinary protein and delay the progress of CKD mainly by inhibiting the SGLT2 receptor in renal tubules, inhibiting the reabsorption of sodium ions and glucose, contracting into the glomerular arteriole through the tubuloglomerular balance, and reducing the pressure on the glomerulus (39). This evidence concerns the gene SLC5A2 and chronic kidney disease.