Table 1 displays the characteristics of participants, including numbers, age, 24-h-urine cortisol levels, and investigated metabolic parameters [weight, body fat mass, waist–arm ratio, waist–hip ratio, blood pressure, glucose, insulin, homeostatic model assessment-insulin resistance (HOMA), HbA1c, cholesterol, triglycerides, HDL, and LDL]. Glucose concentrations (p = 0.0037), 24-h-urine cortisol (p < 0.0001), systolic blood pressure (p = 0.0326), insulin (p = 0.0086), and HOMA (p = 0.0050) in overt CS were higher than in patients with CS in remission and the control group. This evidence concerns the gene INS and Cowden syndrome 1.