At the end of the experiment on day 28, the tumor samples were analyzed, revealing elevated levels of MDA (Figure 6F), as well as increased mRNA expression of ferroptosis biomarkers acyl-coA synthetase long chain family member 4 (Acsl4) (Figure 6G)52 and prostaglandin-endoperoxide synthase 2 (Ptgs2) (Figure 6H),18 in response to TXNDC12 knockdown. This evidence concerns the gene PTGS2 and neoplasm.