TP53 and cancer: To ensure that our reconstructed networks reflect the downstream effect of the real spectra of TP53 mutations occurring in cancer, and investigate how these impact TP53 function and clinical outcome, we interrogated 1,457 cell lines across 22 cancer types from the Cancer Cell Line Encyclopedia (CCLE) and 12,531 cancer samples across 54 cancer types and sub-types in The Cancer Genome Atlas (TCGA) databases.