Specifically, three pivotal negative regulators of ferroptosis, nuclear factor erythroid 2-related factor 2 (Nrf2, encoded by nuclear factor erythroid 2 like 2 (NFE2L2)), glutathione peroxidase 4 (GPX4), and solute carrier family 7 member 11 (SLC7A11), emerge as critical factors in cancer development through their regulation of oxidative stress and lipid peroxidation. This evidence concerns the gene GPX4 and cancer.