RHOA and cancer: Generally, RhoA has a complicated role in various cancer cells; even though some evidence has revealed that RhoA has an oncogenic role in some BC cell lines such as MC7 [28, 82], lots of studies have shown that RhoA inhibition can stimulate cell migration and lead to metastasis in BLBCs and TNBC cell lines like MDA-MB-231, which overall indicate the tumor suppressive role of RhoA in most BC cells [23, 28, 83].