CDK4 and breast cancer: Indeed, ARHGAP11A is one of the upregulated functional gene networks as a target for E2F1. Thus, phosphorylation and inhibition of Rb that occur with cyclin D1-CDK4/6 [77–80] might result in the abnormal activity of E2Fs and can lead to overexpression of ARHGAP11A which ultimately stimulates cell proliferation via cellular movement in various cancers, especially BC [32, 74, 80].