Since the A/C or C/C genotype of PD-L1(rs2890658) has been reported as a risk factor for the carcinogenesis of human cancer [41,42,46,47], the combination of [A/C+C/C of PD-L1 and C/T or T/T of PD-1] should significantly increase in the cases. The gene discussed is PDCD1; the disease is cancer.