For example, Kuroda et al. [58] have found that the Pro allele of the p53 codon 72 polymorphism increases in urothelial cancer cases in lighter smokers, while Khoury et al. [59] and Wang et al. [60] found that genetic differences in cancer risk may be smaller with high carcinogen loads, which is why our findings did not indicate any relationship between smoking and polymorphisms. The gene discussed is TP53; the disease is cancer.