Some studies have also indicated that PD-L1(rs10815225, rs4143815, and rs2890658) polymorphism may be related to the carcinogenesis of human cancer, including gastric cancer and lung cancer [39-42]. Additionally, one meta-analysis has also indicated a significant relation between PD-L1(rs4143815) polymorphism and human cancers. Here, CD274 is linked to lung carcinoma.