This study examined the effects of three healthy lifestyle-related measures on AD, and after 8 weeks of intervention, we found that EX/GCA/EX+GCA all had beneficial effects on (1) hippocampal Aβ deposition, (2) hippocampal neuroinflammation, (3) oxidative stress (4) cognitive performance and partially reversed damage due to AD, possibly through SIRT1/ PGC-1α/BACE1 signaling pathway. This evidence concerns the gene PPARGC1A and Alzheimer disease.