NFKB1 and Alzheimer disease: H2O2, a product of reactive oxygen metabolism, is often involved in the process of neurodegenerative disease together with NF-kB (Hadipour et al., 2020), and in this study, it was found that H2O2 levels were distinctly increased in AD mice compared to the CON group, while in H2O2 decreased distinctly after receiving treatment and was best in GCA + EX, but there was no significant difference between the two groups, EX and GCA.