BACE1 and Alzheimer disease: Interestingly, in addition to PGC-1α, SIRT1 expression was reported to be negatively correlated with BACE1, with SIRT1 overexpression and subsequent downregulation of BACE1 expression in response to exercise or chlorogenic acid being observed in both in vitro and AD models (Marwarha et al., 2014), and Aβ deposition being alleviated.