Interestingly, in addition to PGC-1α, SIRT1 expression was reported to be negatively correlated with BACE1, with SIRT1 overexpression and subsequent downregulation of BACE1 expression in response to exercise or chlorogenic acid being observed in both in vitro and AD models (Marwarha et al., 2014), and Aβ deposition being alleviated. The gene discussed is PPARGC1A; the disease is Alzheimer disease.