While previous studies have suggested that exercise or polyphenols may mediate the activation of SIRT1 to exert a protective effect against AD and that its downstream targets play an important role in inhibiting some of the critical markers of AD, we also hypothesized that the combination of the two would also activate SIRT1 and that it would exert a better effect than its use alone (Springer and Moco, 2019; Zia et al., 2021). Here, SIRT1 is linked to Alzheimer disease.