Of the seven family members, SIRT1 plays a vital role in the treatment of neurodegenerative diseases and is often considered a therapeutic target due to its positive correlation with the structural integrity of neurons in the brain, the ability to learn and to remember, and the possibility that SIRT1 may also have a significant link to the APP hydrolysis pathway in AD (Herskovits and Guarente, 2014). Here, APP is linked to neurodegenerative disease.