PSEN1 and amyloidosis: We must acknowledge certain limitations of our study, the first and most important being the choice of AD model, in which we chose the APP/PS1 mouse, an animal model that relies exclusively on the amyloid hypothesis, which is increasingly questioned and discredited - especially as evidence suggests that, at the clinical stage, it is tauopathy and inflammation, even though amyloidosis may be “related” to the induction of both processes (inverted commas illustrate the ambiguity and incompleteness of the understanding of these critical relationships between AD-causing proteins).