CD4 and hepatocellular carcinoma: The percentages and activities of TAMs, TANs, Tregs, and MDSCs were increased in peripheral blood and tumor tissue of HCC patients, while the activities of NK and NKT cells were declined.3, 19Meanwhile, the percentages of total T cells and CD4+T cells, as well as the activity of NK cells were all decreased in spleen venous blood of HCC patients, indicating the immune system of HCC patients is impaired, and the immune response of spleen is inhibited.