CD8A and gastric cancer: In gastric cancer patients, CD62L positive cells migrated to spleen and produced transforming growth factor (TGF)-β, thus induced the generation of regulatory T cells (Tregs), therefore inhibited immune response.15In gene-modified spontaneous pancreatic cancer mice, immunoinhibitory cells including Tregs, myeloid-derived suppressor cells (MDSCs), and tumor-associated macrophages (TAMs) predominated from the early immune response.17Spleen CD11b+Gr-1intLy6Chicells closely touched with memory CD8+T cells, which made CD8+T cells tolerant.