In ischemic heart disease, monocytes were mobilized from the spleen to ischemic myocardium and repaired the wound.26In lung adenocarcinoma, spleen-derived TAM and TAN precursors migrated to tumor stroma, and promoted tumor growth.18, 27In the treatment of type 2 diabetes with adipose tissue-derived stem cells (ADSCs), spleen-derived interleukin 10 (IL-10) was elevated. Here, IL10 is linked to neoplasm.