Moreover, although the cells in MDAPSF exhibit reduced drug-resistance, the production of the osteocalcin and other biochemical factors (e.g. Ca2+, MMPs, miRNAs) could stimulate the un-transdifferentiated cancer cells to increase their proliferation, production of MMPs, with the reduction of the matrix stiffness, and consequently increase of the cell migration and metastasis. This evidence concerns the gene BGLAP and cancer.