Therefore, the PiT could play a relevant role in the cancer therapy not only to model the disease in high-throughput strategies of drug-screening and to better in vitro recapitulate drug-response that may occur in native tumor environments, but also, in case of some types of tumors, by the endoscopically administration of tunable photopolymerizable hydrogels to sensibilize the cancer cells before the chemotherapy and the surgical removal of the tumor. The gene discussed is IRF6; the disease is cancer.