MAPT and Alzheimer disease: Acute sleep deprivation increases hippocampal protein expression [18], phosphorylation of the brain proteome [19], production/release of proteins (amyloid-beta, tau) associated with Alzheimer’s disease (AD) [20, 21], and microglial activity and amyloid deposition [22] while also decreasing cerebrospinal fluid (CSF)-to-blood clearance of amyloid-beta and tau [23].