Cancer cells that have gone through EMT will make TGF-β produce cytokines that are pro-tumorigenic, including ILEI (Interleukin-like EMT-inducer), HGF (hepatocyte growth factor), EGF (epidermal growth factor) and PDGF (platelet-derived growth factor).49 PDGF is a pro-angiogenic factor that plays a role in several solid tumor growth processes by paracrine and autocrine means. Here, FAM3C is linked to cancer.