IFNAR1 and cancer: Activation of CD95 by cancer cells activates the death-inducing signaling complex (DISC) via the Fas-associated protein with death domain (FADD), caspase-8 and caspase-10 pathways.60 When EMT occurs or if it is continuously stimulated, CD95 can change its nature from pro-apoptotic factor to non-apoptotic factor.61 EMT and chronic stimulation of CD95 will make cancer cells secrete interferon type I (IFNα or IFNβ) which will interact with its receptors (IFNAR1 and IFNAR2).