There is also a decrease in the expression of epithelial markers such as: e-cadherin, cytokeratin, claudin.23,24 Cancer cells that have undergone the EMT process could migrate and metastasize through a mechanism that can convert normal fibroblast cells into cancer associated fibroblasts (CAF) via the Platelet Derived Growth Factor (PDGF) pathway.25 CAF alters the structure and shape of fibroblasts to better support the metastatic process. This evidence concerns the gene CDH1 and cancer.