Through the epithelial to mesenchymal transition (EMT) mechanism, cancer cells can change from an epithelial phenotype to a more mobile mesenchymal phenotype.21 One of the factors that makes cancer stem cells (CSCs) immortal is their ability to avoid apoptosis triggered by the body’s immune system, namely by increasing the expression of cluster of differentiation 95 (CD95) which has an apoptotic function and triggers cancer stemness.22 This evidence concerns the gene FAS and cancer.