In addition, high vimentin levels are significantly associated with the spread and survival of breast cancer cells, allowing recurrence cancer cases.36 This is in line with research by Yamashita in 2013, who stated that vimentin levels are associated with poor prognosis in recurrence breast cancer.37 In addition, research conducted by Winter in 2021 showed an increase in vimentin activating the AKT pathway, which plays a role in increased breast cancer cell proliferation and invasion.38 This evidence concerns the gene AKT1 and cancer.