VIM and neoplasm: Increased vimentin expression is associated with more aggressive tumor cell properties, increased ability to metastasize and poorer prognosis.32 The actin structure of the cytoskeleton is a crucial element in the process of protrusion and cell migration, so that the intermediate cytoskeleton filament, especially vimentin, also plays a role in the process of adhesion and cell spread.33 In addition, vimentin can protect cells against exposure to stress.34