A subgroup analysis was conducted based on factors such as age, sex, systolic BP, diabetes, atrial fibrillation, valvular heart disease, chronic kidney disease, malignancy, CCI, and medication use, including renin–angiotensin–aldosterone system inhibitors, beta-blockers, and mineralocorticoid receptor antagonists (Figure 3). The gene discussed is NR3C2; the disease is diabetes mellitus.