IL6 and endothelial dysfunction: IL-6, like TNF-alpha, can also produce myocardial dysfunction; IL-6 signaling plays a role in harmful effects in the myocardium as cardiac myocyte loss and contributes to the progression of compensatory LV hypertrophy to heart failure, trigger a series of pathological responses, such as oxidative stress, endothelial dysfunction, induction of myocyte apoptosis with adverse remodelling which ultimately leads to cardiomyocyte dysfunction (44).