In the Recently Decompensated Heart Failure Anakinra Response Trial (REDHART) left ventricular ejection fraction (LVEF) < 50% and CRP > 2 mg/L, a good correlation was observed between CRP levels at 12 weeks and changes in peak Vo2 (R = −0.57; P = 0.001) (51). This evidence concerns the gene CRP and heart failure.