A well‐established mouse HCC model induced by hydrodynamic co‐expression of c‐Myc and NRasGV12 oncogenes (c‐Myc/NRasGV12) in the liver was used to determine the role of Usp22 in hepatotumorigenesis (Figure 1A). The gene discussed is USP22; the disease is hepatocellular carcinoma.