The application of L3C7c‐Fc reversed the inhibition mediated by sPD‐L1, and the combination with the CAR NK 92 cell constructed with an affinity‐enhanced antibody targeting GPC3 achieved improved killing capacity toward HCC cells in the presence of sPD‐L1 or mPD‐L1 expressing tumor cells.163. The gene discussed is GPC3; the disease is hepatocellular carcinoma.