Polygonatum kingianum polysaccharides have been observed to activate PPARγ, inhibit LPS-TLR4/NFκB immune responses, reduce the Firmicutes to Bacteroides ratio (F/B ratio), promote adipocyte differentiation, attenuate adipocyte volume, alleviate hepatocyte steatosis, elevate adipokine expression, enhance insulin sensitivity, and mitigate insulin resistance (Gu et al., 2020). This evidence concerns the gene NFKB1 and steatosis.