NR1H4 and familial hypercholesterolemia: Another study reported that psyllium husk regulates the expression levels of FXR and CYP7B1, as well as the levels of cholic acid, deoxycholic acid, lithocholic acid, and ursodeoxycholic acid, thereby controlling hepatic fat content in high-fat diet (HFD) mice and ameliorating hypercholesterolemia and non-alcoholic fatty liver disease (Deng et al., 2022).