Leaves of Tetrastigma hemsleyanum mitigate hepatic lipid accumulation and oxidative stress by modulating the expression of lipid synthesis/catabolism and oxidative stress genes (SREBP-1c/ACC-1/PPAR-α/PPAR-γ/Keap1/Nrf2), attenuating oxidative stress related to NAFLD in mice and reducing lipid accumulation and inflammation (Xiao et al., 2023). The gene discussed is PPARG; the disease is metabolic dysfunction-associated steatotic liver disease.