DEFA5 and obesity due to melanocortin 4 receptor deficiency: Research has proven that electroacupuncture promotes the expression of multiple mucosal innate immunity-related alpha-defensin genes such as Defa20, Defa41, and Defa5, rescuing dysbiotic cecal microbiota, reducing peripheral inflammation factors and alleviating glucose tolerance, playing a role in resisting obesity (Xia et al., 2022).