MAGI2 and schizophrenia: Transgenic mice overexpressing S-SCAM in excitatory forebrain neurons, thus mimicking part of the schizophrenia-associated S-SCAM gene duplication (Walsh et al., 2008), show schizophrenia-related behavioral phenotypes, hyperglutamatergic function, and a reduction in the number of dendritic spines (Zhang et al., 2015).