Interestingly, these transgenic mice show, in addition to a reduced number of dendritic spines, enhanced basal glutamatergic synaptic transmission and schizophrenia-like endophenotypes (Zhang et al., 2015), which is consistent with the duplication of the S-SCAM gene in schizophrenia (Walsh et al., 2008). This evidence concerns the gene MAGI2 and schizophrenia.