Transcriptomic analysis showed significant increases in the expression of Siglec-9 (3.47 vs 2.96, p=0.04) (Figure 1Aii) and Siglec-11 (1.51 vs 0.96, p=0.02) (Figure 1Aiii) in the macular region of AMD retinas compared to healthy controls, while a trend of upregulation (not reaching significance) was observed for Siglec-7 (1.67 vs 1.98, p=0.17; Figure 1Ai). The gene discussed is SIGLEC11; the disease is age-related macular degeneration.