In addition, the leave-one-out sensitivity analysis confirmed that there was almost no significant change in the risk estimations for genetically predicted IL-17 levels and IBD risk after removing 1 SNP at a time, except for the estimations of IL-17RB on UC and IL-17RC on CD from deCODE database (Supplementary Figures 2-17). This evidence concerns the gene IL17A and inflammatory bowel disease.