CRY2 and Alzheimer disease: Analysis of relative mRNA expression of different clock genes in corresponding PBMC samples of the same patient subgroups revealed significant differences in CLOCK, CRY1, CRY2, WEE1 (no change in AD patients) and TIMELESS expression in all subgroups with PAI compared to controls, despite a difference regarding CLOCK expression in CAH and BADx patients (Figure 3).