CD8A and Hyperbilirubinemia: In addition, in the CD8+ T cell/HepaRG and NK cell/HepaRG co-cultures, the function of the MRP2 transporter and the bilirubin glucuronidation capacity of hepatocytes were addressed to provide insight into possible bilirubin metabolism issues regarding conjugation and transport of this molecule which can lead to hyperbilirubinemia, a marker of aldesleukin-mediated hepatotoxicity (13).