The results showed that the expression levels of ACSL6, CYP19A1, LRP2, OSBPL3 and SLCO1A2 were considerably increased, while those of ACOX1, FABP4, PLAAT5, PPARGC1A and TNFAIP8L3 were decreased in colon cancer. The gene discussed is LRP2; the disease is colonic neoplasm.