According to the prognostic model, the risk score of each colon adenocarcinoma patient based on FAM genes can be calculated as follows: Risk Score = Expression of CYP19A1 * 0.31775133 – Expression of ACSL6 * 0.02442698 + Expression of LRP2 * 0.49898014 + Expression of OSBPL3 * 0.21861865 + Expression of SLCO1A2 * 0.13954724 – Expression of ACOX1 * 0.37098995 – Expression of PPARGC1A * 0.11749459 + Expression of TNFAIP8L3 * 0.16809725. The gene discussed is OSBPL3; the disease is colon adenocarcinoma.