We identified ten FAM genes with significantly differential expression and prognostic value, and we constructed a prognostic model with the eight genes that met the screening criteria: ACSL6, TNFAIP8L3, ACOX1, LRP2, OSBPL3, PPARGC1A, CYP19A1, and SLCO1A2. Acyl-CoA synthetase long-chain family member 6 (ACSL6) is responsible for synthesizing long-chain fatty acids, and it is commonly downregulated in most types of cancers except for colorectal cancer (38). Here, ACOX1 is linked to colorectal cancer.