As TNFAIP8L3 is an important transporter of the second messenger for phosphoinositol in FAM and promotes tumour progression, we speculated that this gene might be involved in orchestrating lipid metabolism for both tumour cells and immune cells in the colon cancer TME and might play a pivotal role in FAM in the tumour immune microenvironment. Here, TIPE3 is linked to colonic neoplasm.