F. prausnitzii is capable of immunosuppression through blocking of NF-κB activation and anti-inflammatory cytokine production, and reduced abundance of F. prausnitzii has been observed in inflammatory bowel disease (IBD) subjects[58], indicating a harmonious relationship between mucosal commensals and the host in a healthy gut environment. The gene discussed is NFKB1; the disease is inflammatory bowel disease.