In the present study, to assess the potential prognostic value of P2RY13 expression in human ccRCC, we analyzed gene expression profiles from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases, using the Gene Ontology (GO) enrichment and Gene Set Enrichment Analysis (GSEA) pathways to analyze the biological processes (BPs) involved in protein–protein interaction (PPI) networks to evaluate potential biological interaction networks, which may provide insights into the molecular mechanisms of ccRCC. The gene discussed is P2RY13; the disease is nonpapillary renal cell carcinoma.