We interrogated epistatic associations in a genetic model of cardiac hypertrophy (Fig. 1, blue): induced pluripotent stem cell cardiomyocytes derived from patients with and without hypertrophic cardiomyopathy caused by the cardiac myosin heavy chain (MYH7) p.R403Q variant30 (Fig. 6a). The gene discussed is MYH7; the disease is hypertrophic cardiomyopathy.