PPIA and Alzheimer disease: Other CSF markers 28 showing MS1262 affected/reversed expression included the following (Fig. 6B): Glia maturation factor β (GMFB), a newly characterized G9a-regulated factor in the regulation of neuronal and glial growth and differentiation108; Thy-1 glycoprotein, which was implicated in extensive growth of abnormal neurites in AD 109; proton pump inhibitor A (PPIA), which was related to cognitive decline 110; and SCGC, which is typically transported in synaptic vesicles as a marker of synaptic loss and neuronal injury/degeneration for prognosis in prodromal AD 111.