MAPT and Alzheimer disease: Also, two of these AD/G9a-coregulated proteins were microtubule-associated protein products of MAPT genes, namely, peripheral nervous system Tau (PNS-Tau, UniProt P10637) and Tau-A (or B, C, UniProt B1AQW2) (Fig. S4D).59, 60 Alternative splicing of the MAPT transcript produces multiple protein isoforms, and the unique Tau peptide was present in the central nervous system isoforms.