However, few pathways strongly correlated with AD pathology were identified by transcriptomic analysis of G9a inhibitor (UNC0642)-treated 5XFAD mice.8, 122 Instead, recent multiomics analyses of large cohort samples of AD patients11 identified the proteopathologic nature of AD, i.e., proteomic changes that were not observed at the mRNA level strongly correlated with AD pathology and cognitive decline, which suggested that AD pathogenesis is predominately a translation abnormality. This evidence concerns the gene EHMT2 and Alzheimer disease.