MECP2 and Alzheimer disease: In addition, in the same G9a-interacting complex in AD, MS1262 inhibition also reversed AD-characteristic G9a interactions with proteins involved in postsynaptic neurotransmitter receptor internalization such as Rabphilin-3A (Rph3A), a synaptic vesicle protein47, methyl CpG binding protein 2 (Mecp2) 48, 49, and clathrin-dependent endocytosis such as the hetero-tetrameric assembly protein complex 2 alpha adaptins (AP2A1 and AP2A2)50.