We used the biotin-tagged G9a inhibitor UNC0965 with label-free quantitation (LFQ)27, 29 ChaC-MS13 to identify G9a-interacting proteins in the hippocampus of the 5xFAD mice and cerebral organoids derived from an AD iPSC line F033K with the amyloid precursor protein (APP) V717I mutation30. This evidence concerns the gene APP and Alzheimer disease.