As examples, in correlation with MS1262 rescued synaptic functions (Fig. 4), MS1262 suppressed AD-characteristic expression of proteins associated with synaptic structure and function, such as neuropilin-1 (NRP1),55, 56 tenascin-c (TNC),57 and SH3 And Multiple Ankyrin Repeat Domains 3 (SHANK3)58 (Fig. S4E). This evidence concerns the gene SHANK3 and Alzheimer disease.