The synaptic protein Rph3A associated with Aβ burden47 when Mecp2 was implicated in neuronal endocytosis and synaptic plasticity.48, 49 In line with our finding of similar G9a translational function in chronically inflamed macrophages, these results of G9a interactions with translation regulators confirmed that G9a activity is crucial for global translation of AD-causative proteins. Here, RPH3A is linked to Alzheimer disease.