In addition, in contrast to the fact that MS1262 inhibition of G9a reversed the widespread expression of proteins that are causative in AD pathology, we found that treatment of AD mice by UNC0642 had little effect on the global expression of AD-related proteins in the hippocampus (data not shown); this limited effect was probably due to the low brain permeability/stability or relatively low potency of this compound. Here, EHMT2 is linked to Alzheimer disease.