YTHDC2 and Alzheimer disease: These AD-phenotypic G9a-interacting translation regulators include multiple m6A RNA regulators such as HNRNPA2B1, YTHDC2, and YTHDF2, all of which were implicated in AD.32 Our m6A RNA-to-protein correlation analysis identified G9a/AD-coregulated m6A mRNAs whose protein translation was reversed by MS1262 treatment of AD mice, validating G9a regulation of m6A-mediated translation in AD.