We also noticed that two CSF markers showed AD-upregulated, MS1262-suppressed expression in the hippocampus of AD mice but decreased abundance in patient CSF, namely, MFGE8, which was implicated in Aβ-induced phagoptosis and a potential therapeutic target to prevent neuronal loss in AD 112 and neuronal pentraxin receptor (NPTXR/NPTX2), which was identified as a biomarker of AD progression for CSF-based liquid biopsy 111, 113. This evidence concerns the gene MFGE8 and Alzheimer disease.