Broadly on the basis of MS1262-induced phosphorylation changes, we observed that MS1262 reactivated the interactive pathways involved in calcium signaling, CREB (cAMP-response element-binding protein) signaling in neurons, and synaptogenesis signaling (Fig. 5E), which are suppressed during AD pathogenesis 62, 63, 64. This evidence concerns the gene CREB1 and Alzheimer disease.