Plasma glial fibrillary acidic protein, an astrocyte reactivity biomarkers for AD120 and nitric oxide synthase 1 for synaptic transmission and neuroplasticity121 were MS1262-targeted components of modules M5 post-synaptic density or M11 cell-ECM interaction, respectively, again, major modules strongly correlated to AD neuropathology and cognition. Here, NOS1 is linked to Alzheimer disease.