EHMT2 and Alzheimer disease: In addition, approximately 47% (5xFAD mice) and 42% (APP-NLGF mice) of proteins that showed AD-characteristic dysregulation that was reversed following MS1262 treatment, classified as ‘AD/G9a-coregulated’ proteins, were translated from m6A-tagged RNAs (Fig. S4C) further confirming the function of enzymatically active G9a in regulating translation of AD-related proteins.