Interestingly, increased m6A writer (METTL3, RBM15) and decreased m6A eraser (FTO, ALKBH5) expression along with an overall increase in m6A modification with age/AD-progression in the hippocampus and cortex of various mouse models (APP/PS1, APPNL-G-F/MAPTP301S) and AD patients has been reported previously 51, 52, 53, 54. Here, METTL3 is linked to Alzheimer disease.