Here we show that by expressing a multitude of putative, uncharacterized, tumor antigens within VSV using a cDNA library derived from three different SB-HCC explants (VSV-SB-HCC1,2,3) we observed highly significant improvements compared to anti-PD-L1 ICI alone - even in the absence of added anti-PD-L1 treatment. This evidence concerns the gene CD274 and neoplasm.