Finally, splenocytes from mice treated with the combination of all three putative HCCTAA (VSV-IFNß-Lect2 + VSV-IFNß-Lcn2 + VSV-IFNß-Smagp) + anti-PD-L1 showed no detectable response to SB-HCC 1,2,3 explants (Fig. 6C), suggesting that addition of the Lect2 and/or Smagp antigens may even exert an inhibitory effect upon anti-tumor immunity as generated by Lcn2 alone. This evidence concerns the gene CD274 and hepatocellular carcinoma.