This tumor-expanded population also expressed high levels of Lymphocyte Activation Gene-3 (LAG3, CD223), T-cell immunoglobulin and mucin domain-3 (TIM3), T cell immunoreceptor with Ig and ITIM domains (TIGIT), programmed cell death protein 1 (PD-1) and CD39 which are also associated with terminal effector and exhausted CD8+ T cells43, 44, 45. This evidence concerns the gene HAVCR2 and neoplasm.