Furthermore, histidyl dipeptide synthesizing enzyme carnosine synthase (CARNS) and amino acid transporters (PEPT2 and TAUT)wasmeasured in the gastrocnemius muscles of the sham and TAC-operated mice.<h4>Results</h4>TAC-induced heart failure decreases body weight and gastrocnemius and soleus muscle weights. The gene discussed is SLC15A2; the disease is heart failure.