In particular, JMJD2D overexpression was found in human colorectal tumor specimens; downregulation of JMJD2D compromised colorectal cancer cell proliferation, viability, migration, invasion and xenograft tumor growth; and knockout of Jmjd2d compromised chemically induced colitis-associated colon tumor formation as well as spontaneous tumorigenesis in Apcmin/+ mice (11–14). This evidence concerns the gene KDM4D and colonic neoplasm.