Further, downregulation of JMJD2D with two different shRNAs resulted into less growth and clonogenic activity of DU145 human prostate cancer cells (Figures 4C–E), and similarly JMJD2D downregulation diminished the growth of human LNCaP prostate cancer cells (Supplementary Figure 1). The gene discussed is KDM4D; the disease is Familial prostate cancer.