For the atrial natriuretic peptide receptor gene NPR1, a potential role in prostate cancer is controversial: while atrial natriuretic peptide displayed anti-cancer activity in prostate adenocarcinoma cells (82), NPR1 ablation caused apoptosis that suggests a tumor-promoting role for NPR1 by facilitating cancer cell survival (83). This evidence concerns the gene NPPA and prostate adenocarcinoma.