From those, we selected 8 genes (CBLC, METTL27, COL4A5, GLIS3, NPR1, OSR2, PLAGL1, RSPO3) based on their known or their unanticipated function in prostate cancer (see below and Discussion) and corroborated their altered expression by quantitative RT-PCR (Figure 6B). This evidence concerns the gene COL4A5 and Familial prostate cancer.