From those, we selected 8 genes (CBLC, METTL27, COL4A5, GLIS3, NPR1, OSR2, PLAGL1, RSPO3) based on their known or their unanticipated function in prostate cancer (see below and Discussion) and corroborated their altered expression by quantitative RT-PCR (Figure 6B). This evidence concerns the gene METTL27 and Familial prostate cancer.