RSPO3 and Familial prostate cancer: From those, we selected 8 genes (CBLC, METTL27, COL4A5, GLIS3, NPR1, OSR2, PLAGL1, RSPO3) based on their known or their unanticipated function in prostate cancer (see below and Discussion) and corroborated their altered expression by quantitative RT-PCR (Figure 6B).